Author

C. R. Guzzo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:protein folding & dynamics· 3 Organism:bacteria (other)· 2 Assay:proteomics· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. S. d. Souza· 3 shared C. S. Farah· 2 shared R. F. d. Souza· 2 shared R. F. de Souza· 2 shared R. R. G. Machado· 2 shared A. L. Leal· 1 shared A. P. Barbosa· 1 shared A. Patel· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersBiophysics

A. S. d. Souza

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The protective function of an immunity protein against the cis-toxic effects of a Xanthomonas Type IV Secretion System Effector

G. Oka, D. P. Souza, G. G. Sgro, C. R. Guzzo, G. Dunger, C. S. Farah

This paper investigates how immunity proteins protect against cis-intoxication by the Xanthomonas citri Type IV Secretion System, showing that X-Tfis specifically prevent self-intoxication via autolysis.

bioRxiv · Aug 28, 2023Biochemistry

Cooperative and structural relationships of the trimeric Spike with infectivity and antibody escape of the strains Delta (B.1.617.2) and Omicron (BA.2, BA.5, and BQ.1)

A. S. d. Souza, R. F. d. Souza, C. R. Guzzo

This study simulates the trimeric Spike protein of SARS-CoV-2 variants to analyze how specific mutations affect infectivity and antibody resistance.

bioRxiv · Mar 6, 2023Biophysics

Molecular dynamics simulations of the Spike trimeric ectodomain of the SARS-CoV-2 Omicron variant: structural relationships with infectivity, evasion to immune system and transmissibility

V. M. d. F. Amorim, R. F. de Souza, A. S. d. Souza, C. R. Guzzo

The paper uses molecular dynamics simulations to analyze structural differences between SARS-CoV-2 Spike proteins of the Omicron and wild-type variants, linking conformational flexibility to increased infectivity, immune evasion, and transmissibility.

bioRxiv · Feb 14, 2022Biophysics

Immunization with SARS-CoV-2 nucleocapsid protein triggers a pulmonary immune response in rats

E. K. V. B. Silva, C. G. Bomfim, A. P. Barbosa, P. Noda, I. L. Noronha, B. H. V. Fernandes, R. R. G. Machado, E. L. Durigon, S. Catanozi, L. G. Rodrigues, F. Pieroni, S. Lima, Z. A. J. Queiroz, I. Charlie-Silva, L. K. R. Silveira, , C. Fanelli

This study shows that immunizing rats with SARS-CoV-2 nucleocapsid protein induces specific lung immune responses and safe antibody production without toxicity.

bioRxiv · Aug 24, 2021 · PreprintImmunology

Molecular and functional basis of a novel Amazonian Dark Earth Esterase 1 (Ade1) with hysteresis behavior and quorum-quenching activity

T. G. C. Vinces, A. S. d. Souza, C. Carvalho, R. D. Teixeira, B. A. P. Bismara, E. J. Vicente, J. O. Pereira, R. F. d. Souza, M. Yonamine, S. R. Marana, C. S. Farah, C. R. Guzzo

The paper identifies and characterizes a novel esterase, Ade1, from Amazonian Dark Earth soils, revealing its hysteresis behavior and quorum-quenching activity through molecular dynamics simulations.

bioRxiv · Dec 16, 2020 · PreprintBiochemistry

Hypertonic saline solution inhibits SARS-CoV-2 in vitro assay

R. R. G. Machado, T. Glaser, D. B. Araujo, L. L. Petiz, D. B. L. Oliveira, G. S. Durigon, A. L. Leal, J. R. R. Pinho, L. C. S. Ferreira, H. Ulrich, E. L. R. Durigon, C. R. Guzzo

This study shows that hypertonic saline solution inhibits SARS-CoV-2 replication in Vero cells through an intracellular mechanism, not by disrupting spike protein-receptor interaction.

bioRxiv · Aug 4, 2020Microbiology

A Superfamily of T6SS Antibacterial Effectors Displaying L,D-carboxypeptidase Activity Towards Peptidoglycan

S. Sibinelli-Sousa, J. T. Hespanhol, G. G. Nicastro, B. Y. Matsuyama, S. Mesnage, A. Patel, R. F. de Souza, C. R. Guzzo, E. Bayer-Santos

The paper identifies Tae5STM as a T6SS effector with L,D-carboxypeptidase activity that cleaves peptidoglycan, revealing a new superfamily of bacterial effectors involved in interbacterial competition.

bioRxiv · Feb 18, 2020Microbiology