Author

C. S. Farah

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biochemistry· 2 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:bacteria (other)· 6 Research Focus:host-pathogen & immune response· 5 Assay:proteomics· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

C. R. Guzzo· 2 shared E. Bayer-Santos· 2 shared E. E. Llontop· 2 shared G. G. Sgro· 2 shared I. Todeschini· 2 shared R. F. de Souza· 2 shared W. Cenens· 2 shared A. C. Neto· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiochemistry

C. R. Guzzo

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

The protective function of an immunity protein against the cis-toxic effects of a Xanthomonas Type IV Secretion System Effector

G. Oka, D. P. Souza, G. G. Sgro, C. R. Guzzo, G. Dunger, C. S. Farah

This paper investigates how immunity proteins protect against cis-intoxication by the Xanthomonas citri Type IV Secretion System, showing that X-Tfis specifically prevent self-intoxication via autolysis.

bioRxiv · Aug 28, 2023Biochemistry

Uncovering the association mechanism between two intrinsically flexible proteins

A. L. Davalos, J. D. Rivera, D. C. Favaro, R. J. d. Oliveira, G. Carretero, C. D. Lacerda, I. M. Cuccovia, M. V. C. Cardoso, C. S. Farah, R. K. Salinas

The paper investigates how two intrinsically flexible proteins interact, finding that binding occurs via conformational selection and temperature affects the pathway to the native complex.

bioRxiv · Jun 19, 2023Biophysics

Antibacterial T6SS effectors with a VRR-Nuc domain induce target cell death via DNA Double-Strand Breaks

J. T. Hespanhol, D. E. Sanchez-Limache, G. G. Nicastro, L. Mead, E. E. Llontop, G. Chagas-Santos, C. S. Farah, R. F. de Souza, R. d. S. Galhardo, A. Lovering, E. Bayer-Santos

The paper identifies T6SS effectors in Salmonella that induce DNA double-strand breaks and cell death in competitors.

bioRxiv · Dec 26, 2021 · PreprintMicrobiology

Isolation of a Bacillus safensis from mine tailings in Peru, genomic characterization and characterization of its cyanide- degrading enzyme CynD

S. Justo Arevalo, D. Zapata Sifuentes, A. Cuba Portocarrero, M. Brescia Reategui, C. Monge Pimentel, L. Farage Martins, P. Marques Pierry, C. Morais Piroupo, A. Guerra Santa Cruz, M. Quinones Aguilar, C. S. Farah, J. C. Setubal, A. M. da Silva

The paper isolates a Bacillus safensis strain from mine tailings and characterizes its cyanide-degrading enzyme CynD, showing its activity at high pH and strong induction by cyanide.

bioRxiv · Nov 27, 2021Microbiology

Resource sharing by outer membrane vesicles from a citrus pathogen

G. G. Araujo, M. M. Conforte, A. D. da Purificacao, I. Todeschini, E. E. Llontop, C. B. Angeli, A. Inague, M. Y. Yoshinaga, R. F. de Souza, R. Papai, M. S. Luz, S. Miyamoto, G. Palmisano, C. S. Farah, C. R. Carvalho

This study identifies outer membrane vesicles from Xanthomonas citri as resource-sharing structures containing nutrients and enzymes that support bacterial growth and virulence.

bioRxiv · Apr 26, 2021 · PreprintMicrobiology

Molecular and functional basis of a novel Amazonian Dark Earth Esterase 1 (Ade1) with hysteresis behavior and quorum-quenching activity

T. G. C. Vinces, A. S. d. Souza, C. Carvalho, R. D. Teixeira, B. A. P. Bismara, E. J. Vicente, J. O. Pereira, R. F. d. Souza, M. Yonamine, S. R. Marana, C. S. Farah, C. R. Guzzo

The paper identifies and characterizes a novel esterase, Ade1, from Amazonian Dark Earth soils, revealing its hysteresis behavior and quorum-quenching activity through molecular dynamics simulations.

bioRxiv · Dec 16, 2020 · PreprintBiochemistry

Zebrafish studies on the vaccine candidate to COVID-19, the Spike protein: Production of antibody and adverse reaction

B. H. V. Fernandes, N. M. Feitosa, A. P. Barbosa, C. G. Bomfim, A. M. Garnique, F. I. Gomes, R. T. Nakajima, M. A. Belo, S. F. Eto, D. C. Fernandes, G. Malafaia, W. G. Manrique, G. Conde, R. R. Rosales, I. Todeschini, , Veras

This study uses zebrafish to test a COVID-19 vaccine candidate, showing antibody production and adverse reactions similar to human severe cases.

bioRxiv · Oct 20, 2020 · PreprintImmunology

Bactericidal Type IV Secretion System Homeostasis in Xanthomonas citri

W. Cenens, M. O. Andrade, C. S. Farah

This study shows that Xanthomonas citri constitutively produces a type IV secretion system (T4SS) at a low basal level, regulated by CsrA to balance metabolic costs and competitiveness.

bioRxiv · May 26, 2019Microbiology

The opportunistic pathogen Stenotrophomonas maltophilia utilizes a type IV secretion system for interbacterial killing

E. Bayer-Santos, W. Cenens, B. Y. Matsuyama, G. Di Sessa, I. D. V. Mininel, C. S. Farah

This study identifies a type IV secretion system in Stenotrophomonas maltophilia that kills competitor bacteria by secreting toxins, expanding knowledge of T4SS functions in interbacterial competition.

bioRxiv · Feb 21, 2019Microbiology