HP1β Chromo Shadow Domain facilitates H2A ubiquitination for BRCA1 recruitment at DNA double-strand breaks
T. Pandita, V. K. Charaka, S. Chakraborty, C.-L. Tsai, X. Wang, R. Pandita, J. Taineer, C. R. Hunt
This study identifies HP1β's chromo shadow domain as essential for promoting H2A ubiquitination and BRCA1 recruitment at DNA double-strand breaks to facilitate homologous recombination repair.
bioRxiv · Jan 11, 2022 · PreprintCell Biology