H. P. Harding

A genome wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α

The paper uses a CRISPR/Cas9 screen to identify calreticulin as a repressor of ATF6α signaling in the unfolded protein response.

Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the Integrated Stress Response

The paper identifies a mechanism by which eIF2γ binding to PPP1R15A enhances catalytic efficiency of the holophosphatase that terminates the integrated stress response.

Higher order phosphatase-substrate contacts terminate the Integrated Stress Response

The paper presents a Cryo-EM structure of the PP1c/PPP1R15A/G-actin complex that terminates the Integrated Stress Response by positioning eIF2's phosphoserine-51 at the active site.

ISRIB blunts the integrated stress response by allosterically antagonising the inhibitory effect of phosphorylated eIF2 on eIF2B

This study shows ISRIB inhibits the integrated stress response by antagonizing eIF2(P)-induced inhibition of eIF2B through allosteric effects.

Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers

This study identifies genes and cargo receptors involved in the ER export of pathogenic α1-antitrypsin polymers using a CRISPR screen.

GDF15 and the beneficial actions of metformin in pre-diabetes

This study shows metformin increases GDF15 levels, which is necessary for its weight loss and insulin-sensitizing effects in both humans and mice.