ISRIB blunts the integrated stress response by allosterically antagonising the inhibitory effect of phosphorylated eIF2 on eIF2B
A. Zyryanova, K. Kashiwagi, C. Rato, H. P. Harding, A. Crespillo-Casado, L. Perera, A. Sakamoto, M. Nishimoto, M. Yonemochi, M. Shirouzu, T. Ito, D. Ron
This study shows ISRIB inhibits the integrated stress response by antagonizing eIF2(P)-induced inhibition of eIF2B through allosteric effects.
bioRxiv · Sep 28, 2020Biochemistry