B. Martins

Cryo-electron tomography reveals the nanoscale architecture of the actin cortex in cellular blebs

This study uses cryo-ET to reveal the nanoscale 3D organization of cortical actin in cellular blebs, showing short and straight actin filaments and structural parameters.

Cancer Prevalence Across Vertebrates

The paper analyzes cancer prevalence across 292 vertebrate species and finds that neoplasia prevalence increases with adult weight and mutation rate but decreases with gestation time.

A novel immunopeptidomic-based pipeline for the generation of personalized oncolytic cancer vaccines

The paper describes a pipeline for generating personalized oncolytic cancer vaccines using immunopeptidomic data and validates it in a murine colon tumor model.

A personalized anti-cancer vaccine for melanoma based on an approved vaccine against measles, mumps, and rubella

This paper repurposes an approved MMR vaccine in a PeptiENV platform to enhance anti-melanoma immunity and improve response to checkpoint inhibitors.

Revealing the polarity of actin filaments by cryo-electron tomography

This study develops a method to determine actin filament polarity in cryo-tomograms and shows a linear relationship between actin polarity and distance from the apical boundary in focal adhesions.

Novel personalized cancer vaccine platform based on Bacillus Calmette-Guerin

This paper develops a BCG-based cancer vaccine platform that enhances anti-tumor immune responses by attaching tumor-specific peptides to BCG, improving therapeutic outcomes in mouse models.

Uncovered genetic diversity in Hemidactylus mabouia (Reptilia: Gekkonidae) from Madeira Island reveals uncertain sources of introduction

The study identifies two distinct genetic lineages of Hemidactylus mabouia in Madeira Island, challenging previous assumptions about its introduction source.

FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis

This study identifies FGFR4 as a kinase that phosphorylates MST1, thereby inhibiting MST1/2-dependent apoptosis and promoting breast cancer cell survival.

Conformational states during vinculin unlocking differentially regulate focal adhesion properties

This study investigates how vinculin's conformational changes affect focal adhesion properties by analyzing the transition from closed to open states.