Structure of the Human Volume Regulated Anion Channel
J. M. Kefauver, K. Saotome, A. E. Dubin, J. Pallesen, C. A. Cottrell, G. Hong, S. M. Cahalan, Z. Qiu, C. S. Crowley, T. Whitwam, W.-H. Lee, A. B. Ward, A. Patapoutian
The paper reports the high-resolution cryo-EM structure of human SWELL1, revealing its trimer of dimers assembly and identifying a charged residue critical for pore function in VRAC.
bioRxiv · May 16, 2018Biochemistry