Z. Qiu

Mechanical Netrin-1-DCC Coupling Mediates Netrin-1-induced Axonal Haptotaxis

This study shows that netrin-1-induced axonal haptotaxis is mediated by mechanical coupling between netrin-1 and its receptor DCC, facilitated by shootin1a and actin flow.

IRF8-mutant B cell lymphoma evades immunity through a CD74-dependent deregulation of antigen processing and presentation in MHC CII complexes

This study shows that IRF8 mutations in DLBCL lymphomas impair antigen processing and presentation by reducing CD74 and HLA-DM, leading to immune evasion and increased tumor burden.

Mecp2 Fine-tunes Quiescence Exit by Targeting Nuclear Receptors

This study shows Mecp2 negatively regulates quiescence exit by activating metabolic genes and repressing proliferation genes, with nuclear receptors Rara and Nr1h3 playing a key role.

Unravelling Biosynthesis and Biodegradation Potentials of Microbial Dark Matters in Hypersaline Lakes

This study identifies novel biosynthesis and biodegradation potentials in microbial dark matter from hypersaline lakes, expanding genetic resources for biotechnology.

ATP-releasing SWELL1 channel in spinal microglia contributes to neuropathic pain

This study identifies VRAC as an ATP-releasing channel in microglia contributing to neuropathic pain and shows dicumarol inhibits it, reducing pain behaviors in mice.

A patterned human heart tube organoid model generated by pluripotent stem cell self-assembly

This paper develops a patterned human heart tube organoid model using pluripotent stem cell self-assembly, showing anterior-posterior patterning and multiple cardiac cell types.

Inhibition of the proton-activated chloride channel PAC by PIP2

This study identifies PIP2 as an inhibitor of the PAC channel, revealing its binding site and mechanism through structural and electrophysiological analyses.

Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC

This study identifies key residues and structural interactions involved in pH-dependent desensitization of the proton-activated chloride (PAC) channel using electrophysiology, mutagenesis, and molecular dynamics simulations.

Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques

This study shows a single-dose AAV-based vaccine induces long-lasting neutralizing antibodies against multiple SARS-CoV-2 variants in rhesus macaques.

Precursor abundance influences divergent antigen specific CD8+ T cell responses after Yersinia pseudotuberculosis foodborne infection

This study shows that higher precursor abundance of YopE69-77-specific CD8+ T cells explains their dominance over OVA257-264-specific cells during Y. pseudotuberculosis infection.

Complete genome and phylogenetic analysis of bovine papillomavirus type 15 in Southern Xinjiang dairy cow

The paper reports the complete genome sequence of a novel BPV type 15 strain from a cow in southern Xinjiang and places it phylogenetically within the Xipapillomavirus genus.

Enrichment of short mutant cell-free DNA fragments enhanced detection of pancreatic cancer

This study introduces SLHC-seq, a new targeted sequencing method that improves detection of pancreatic cancer by analyzing short mutant cfDNA fragments, enabling earlier diagnosis.

Structure of the Human Volume Regulated Anion Channel

The paper reports the high-resolution cryo-EM structure of human SWELL1, revealing its trimer of dimers assembly and identifying a charged residue critical for pore function in VRAC.