Author

T. Whitwam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Patapoutian· 3 shared S. Cahalan· 2 shared S. Murthy· 2 shared A. B. Ward· 1 shared A. Dubin· 1 shared A. E. Dubin· 1 shared A. I. Su· 1 shared A. Ward· 1 shared

Activity by Year

2017-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBiophysics

A. Patapoutian

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Author profile →

3 papers

Recent·Most cited

OSCA/TMEM63 are an Evolutionarily Conserved Family of Mechanically Activated Ion Channels

S. Murthy, A. Dubin, T. Whitwam, S. Jojoa Cruz, S. Cahalan, S. A. R. Mosavi, A. Ward, A. Patapoutian

The paper identifies OSCA proteins in plants and their homologues TMEM63 in animals as evolutionarily conserved mechanosensitive ion channels involved in mechanotransduction.

bioRxiv · Sep 4, 2018Biophysics

Structure of the Human Volume Regulated Anion Channel

J. M. Kefauver, K. Saotome, A. E. Dubin, J. Pallesen, C. A. Cottrell, G. Hong, S. M. Cahalan, Z. Qiu, C. S. Crowley, T. Whitwam, W.-H. Lee, A. B. Ward, A. Patapoutian

The paper reports the high-resolution cryo-EM structure of human SWELL1, revealing its trimer of dimers assembly and identifying a charged residue critical for pore function in VRAC.

bioRxiv · May 16, 2018Biochemistry

Common Piezo1 allele in African populations causes xerocytosis and attenuates Plasmodium infection

S. Ma, S. Cahalan, R. Lohia, G. LaMonte, W. Zeng, S. Murthy, E. Paytas, N. D. Grubaugh, R. Gamini, L. Berry, V. Lukacs, T. Whitwam, M. Loud, A. I. Su, K. G. Andersen, , A. Patapoutian

The paper identifies a common Piezo1 variant in African populations that causes xerocytosis and reduces Plasmodium infection.

bioRxiv · Jul 6, 2017Physiology