Author

C. S. Law

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

A. K. Shum· 3 shared Z. Deng· 3 shared F. O. Ho· 2 shared B. J. Backes· 1 shared J.-S. Shin· 1 shared K. D. Jones· 1 shared K. M. Wang· 1 shared K. Mukai· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersImmunology

A. K. Shum

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3 papers

Recent·Most cited

Activated STING in the thymus alters T cell development and selection leading to autoimmunity

Z. Deng, C. S. Law, S. Kurra, N. Simchoni, A. K. Shum

This study shows STING activation in thymic epithelial cells disrupts T cell selection and promotes autoimmunity by altering interferon signaling and macroautophagy.

bioRxiv · Feb 17, 2024 · PreprintImmunology

A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome

A. K. Shum, Z. Deng, Z. Chong, C. S. Law, K. Mukai, F. O. Ho, T. Martinu, B. J. Backes, W. L. Eckalbar, T. Taguchi

This study shows that defective COPI transport of STING due to COPA mutations leads to immune dysregulation and type I interferon signaling in COPA syndrome.

bioRxiv · May 20, 2020Immunology

A defect in thymic tolerance causes T cell-mediated autoimmunity in a murine model of COPA syndrome

Z. Deng, C. S. Law, F. O. Ho, K. M. Wang, K. D. Jones, J.-S. Shin, A. K. Shum

A murine model of COPA syndrome shows that thymic tolerance defects lead to T cell-mediated autoimmunity and lung disease similar to human patients.

bioRxiv · Jan 21, 2020Immunology