A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome
A. K. Shum, Z. Deng, Z. Chong, C. S. Law, K. Mukai, F. O. Ho, T. Martinu, B. J. Backes, W. L. Eckalbar, T. Taguchi
This study shows that defective COPI transport of STING due to COPA mutations leads to immune dysregulation and type I interferon signaling in COPA syndrome.
bioRxiv · May 20, 2020Immunology