Author

C. S. Metcalf

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

K. S. Wilcox· 3 shared C. A. Reilly· 2 shared C. D. Pernici· 2 shared E. J. Dahle· 2 shared J. A. Mensah· 2 shared K. J. Johnson· 2 shared P. J. West· 2 shared A. Spink· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersPharmacology & Toxicology

K. S. Wilcox

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4 papers

Recent·Most cited

Utilizing an acute hyperthermia-induced seizure test and pharmacokinetic studies to establish optimal dosing regimens in a mouse model of Dravet syndrome

J. A. Mensah, K. Johnson, T. Freeman, C. A. Reilly, J. E. Rower, C. S. Metcalf, K. S. Wilcox

This study evaluates combination therapies for Dravet Syndrome using a mouse model, finding that triple-drug regimens enhance seizure control through potential drug interactions.

bioRxiv · Oct 3, 2023Pharmacology & Toxicology

Breathing dysfunction and alveolar damage in a mouse model of Dravet syndrome

M.-J. Goh, C. E. Deering-Rice, J. Nguyen, E. Duyvesteyn, A. Venosa, C. A. Reilly, C. S. Metcalf

This study examines breathing dysfunction and alveolar damage in a mouse model of Dravet syndrome, finding age-related differences in respiratory responses and lung tissue damage that may contribute to SUDEP.

bioRxiv · May 20, 2022 · PreprintPhysiology

Evaluation of spontaneous seizure activity, sex-dependent differences, behavioral comorbidities, and alterations in CA1 neuron firing properties in a mouse model of Dravet Syndrome

C. D. Pernici, A. Spink, E. J. Dahle, K. J. Johnson, C. S. Metcalf, P. J. West, K. S. Wilcox

bioRxiv · Jun 16, 2021 · PreprintPharmacology & Toxicology

Development of an Antiseizure Drug Screening Platform for Dravet Syndrome at the NINDS contract site for the Epilepsy Therapy Screening Program

C. D. Pernici, J. A. Mensah, E. J. Dahle, K. J. Johnson, L. J. Handy, L. L. Buxton, M. D. Smith, P. J. West, C. S. Metcalf, K. S. Wilcox

This paper evaluates a mouse model of Dravet syndrome for antiseizure drug screening, finding that it is highly refractory to common ASDs but responsive to specific treatments like clobazam and valproic acid.

bioRxiv · Dec 1, 2020Pharmacology & Toxicology