Author

C. S. Tran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Organism:mouse· 1

Frequent Co-Authors

R. Bartenschlager· 4 shared V. Lohmann· 4 shared J.-Y. Lee· 3 shared O. Colasanti· 3 shared P. Meuleman· 3 shared M. Heikenwaelder· 2 shared R. Burm· 2 shared S. Faure-Dupuy· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMicrobiology

R. Bartenschlager

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Phosphatidylinositol 4-kinase III alpha governs cytoskeletal organization for invasiveness of liver cancer cells

C. S. Tran, J. Kersten, M. Breinig, J. Yan, T. Poth, O. Colasanti, T. Riedl, S. Faure-Dupuy, S. Diehl, L. Verhoye, T.-F. Li, M. Lingemann, P. Schult, G. Ahlen, L. Frelin, , V. Lohmann

This study identifies PI4KIII's role in promoting liver cancer invasiveness through cytoskeletal reorganization via PIK3C2γ and Akt2/paxillin-cofilin signaling.

bioRxiv · May 22, 2023Cell Biology

Comparison of HAV and HCV infections in vivo and in vitro reveals distinct patterns of innate immune evasion and activation

O. Colasanti, R. Burm, H.-E. Huang, T. Riedl, J. Traut, N. Gillich, T.-F. Li, L. Corneillie, S. Faure-Dupuy, O. Gruenvogel, D. Heide, J.-Y. Lee, C. S. Tran, U. Merle, M. Chironna, , V. Lohmann

This study compares HAV and HCV infections in vivo and in vitro, revealing that HAV induces an innate immune response via MDA5/LGP2 with limited protease-mediated suppression, while HCV activates TLR3 without TRIF cleavage.

bioRxiv · Nov 7, 2022 · PreprintImmunology

A Hepatitis C virus genotype 1b post transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo

C. Heuss, P. Rothhaar, R. Burm, J.-Y. Lee, U. Haselmann, L. J. Ströh, P. Ralfs, O. Colasanti, C. S. Tran, N. Schäfer, P. Schnitzler, U. Merle, R. Bartenschlager, A. H. Patel, F. Graw, , V. Lohmann

This paper develops an efficient HCV genotype 1b infectious cell culture model through adaptation, enabling vaccine development and understanding viral evolution post-transplant.

bioRxiv · Mar 28, 2022Microbiology

Convergent use of phosphatidic acid for Hepatitis C virus and SARS-CoV-2 replication organelle formation

K. Tabata, V. Prasad, D. Paul, J.-Y. Lee, M.-T. Pham, W.-I. Twu, C. J. Neufeldt, M. Cortese, B. Cerikan, C. S. Tran, C. Luechtenborg, P. Vkovski, K. Hoermann, A. Mueller, C. Zitzmann, , R. Bartenschlager

This study identifies phosphatidic acid as critical for double membrane vesicle formation in HCV and SARS-CoV-2 replication, suggesting host-targeted PA synthesis inhibition as a therapeutic strategy.

bioRxiv · May 10, 2021Microbiology