Author

P. Meuleman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cell Biology· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

C. S. Tran· 3 shared O. Colasanti· 3 shared R. Bartenschlager· 3 shared V. Lohmann· 3 shared J.-Y. Lee· 2 shared M. Heikenwaelder· 2 shared R. Burm· 2 shared S. Faure-Dupuy· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

C. S. Tran

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Phosphatidylinositol 4-kinase III alpha governs cytoskeletal organization for invasiveness of liver cancer cells

C. S. Tran, J. Kersten, M. Breinig, J. Yan, T. Poth, O. Colasanti, T. Riedl, S. Faure-Dupuy, S. Diehl, L. Verhoye, T.-F. Li, M. Lingemann, P. Schult, G. Ahlen, L. Frelin, , V. Lohmann

This study identifies PI4KIII's role in promoting liver cancer invasiveness through cytoskeletal reorganization via PIK3C2γ and Akt2/paxillin-cofilin signaling.

bioRxiv · May 22, 2023Cell Biology

Comparison of HAV and HCV infections in vivo and in vitro reveals distinct patterns of innate immune evasion and activation

O. Colasanti, R. Burm, H.-E. Huang, T. Riedl, J. Traut, N. Gillich, T.-F. Li, L. Corneillie, S. Faure-Dupuy, O. Gruenvogel, D. Heide, J.-Y. Lee, C. S. Tran, U. Merle, M. Chironna, , V. Lohmann

This study compares HAV and HCV infections in vivo and in vitro, revealing that HAV induces an innate immune response via MDA5/LGP2 with limited protease-mediated suppression, while HCV activates TLR3 without TRIF cleavage.

bioRxiv · Nov 7, 2022 · PreprintImmunology

A Hepatitis C virus genotype 1b post transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo

C. Heuss, P. Rothhaar, R. Burm, J.-Y. Lee, U. Haselmann, L. J. Ströh, P. Ralfs, O. Colasanti, C. S. Tran, N. Schäfer, P. Schnitzler, U. Merle, R. Bartenschlager, A. H. Patel, F. Graw, , V. Lohmann

This paper develops an efficient HCV genotype 1b infectious cell culture model through adaptation, enabling vaccine development and understanding viral evolution post-transplant.

bioRxiv · Mar 28, 2022Microbiology

Human hepatocyte PNPLA3 148M exacerbates rapid non-alcoholic steatohepatitis development in chimeric mice

M. Kabbani, E. Michailidis, S. Steensels, C. G. Fulmer, J. M. Luna, J. Le Pen, M. Tardelli, B. Razooky, I. Ricardo-Lax, C. Zou, B. Zeck, A. F. Stenzel, C. Quirk, L. Foquet, A. W. Ashbrook, , Y. P. de Jong

This study shows that the PNPLA3 148M variant in human hepatocytes worsens non-alcoholic steatohepatitis in chimeric mice on a hypercaloric diet.

bioRxiv · Nov 19, 2020 · PreprintPathology

New insights into the ORF2 capsid protein, a key player of the hepatitis E virus lifecycle

M. Ankavay, C. Montpellier, I. M. Sayed, J.-M. Saliou, C. Wychowski, L. Saas, S. Duvet, C.-M. Aliouat-Denis, R. Farhat, V. de Masson d'Autume, P. Meuleman, J. D. Dubuisson, L. Cocquerel

This study characterizes the glycosylation of HEV ORF2 protein and its role in viral lifecycle, showing that glycosylation does not affect particle assembly but contributes to antigenicity and nuclear translocation of ORF2i.

bioRxiv · Oct 5, 2018Microbiology