Queuine is a nutritional regulator of Entamoeba histolytica response to oxidative stress and a virulence attenuator
S. Nagaraja, M. W. Cai, J. Sun, H. Varet, L. Sarid, Y. Shaulov, M. Trebicz-Geffen, M. Mazumdar, R. Legendre, J.-Y. Coppee, T. Begley, P. C. Dedon, S. Gourinath, N. Guillen, Y. Saito-Nakano, , S. Ankri
This study shows queuine, a gut bacterial product, enhances Entamoeba histolytica's oxidative stress resistance while reducing its virulence by modifying tRNAs and altering gene expression.
bioRxiv · Apr 30, 2020Microbiology