Author

T. Begley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

j. Sheng· 2 shared A. Sinha· 1 shared C. Chan· 1 shared C. Liang· 1 shared C. Shimokawa· 1 shared F. Shen· 1 shared H. Hisaeda· 1 shared H. L. Loo· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBiochemistry

j. Sheng

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Author profile →

4 papers

Recent·Most cited

An RNA modification enzyme directly senses reactive oxygen species for translational regulation in Enterococcus faecalis

W. L. Lee, A. Sinha, L. N. Lam, H. L. Loo, J. Liang, P. Ho, C. Liang, C. Chan, T. Begley, K. A. Kline, P. Dedon

The paper identifies an RNA modification enzyme in Enterococcus faecalis that senses reactive oxygen species and regulates translation of stress-response proteins.

bioRxiv · Oct 12, 2022 · PreprintMicrobiology

Nature-Inspired Chemical Probes for in-cell Labeling of Lipidized RNA and Identification of New Regulatory Enzymes

H. Zhou, Y. Li, J. Zhang, L. Wang, Y. Y. Zheng, T. Begley, j. Sheng, R. Wang

The paper develops chemical labeling strategies to tag lipid-modified RNAs and identify new regulatory enzymes involved in prenylation.

bioRxiv · May 17, 2022 · PreprintBiochemistry

Base Pairing and Functional Insights into N3-methylcytidine (m3C) in RNA

S. Mao, P. Haruehanroengra, S. V. Ranganathan, F. Shen, T. Begley, J. Sheng

This study investigates the effects of N3-methylcytidine (m3C) modification on RNA base pairing and reverse transcription, showing its impact on stability, discrimination, and mutation induction.

bioRxiv · Aug 27, 2020Biochemistry

Queuine is a nutritional regulator of Entamoeba histolytica response to oxidative stress and a virulence attenuator

S. Nagaraja, M. W. Cai, J. Sun, H. Varet, L. Sarid, Y. Shaulov, M. Trebicz-Geffen, M. Mazumdar, R. Legendre, J.-Y. Coppee, T. Begley, P. C. Dedon, S. Gourinath, N. Guillen, Y. Saito-Nakano, , S. Ankri

This study shows queuine, a gut bacterial product, enhances Entamoeba histolytica's oxidative stress resistance while reducing its virulence by modifying tRNAs and altering gene expression.

bioRxiv · Apr 30, 2020Microbiology