Author

S. Gourinath

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

C. Shimokawa· 1 shared D. Kumar· 1 shared H. Hisaeda· 1 shared H. Varet· 1 shared J. Sun· 1 shared J.-Y. Coppee· 1 shared L. Sarid· 1 shared M. Mazumdar· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMicrobiology

C. Shimokawa

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2 papers

Recent·Most cited

Machine learning-based modulation of Ca2+-binding affinity in EFhand proteins and comparative structural insights into site-specific cooperative binding

M. Mazumder, S. Kumar, D. Kumar, S. Gourinath

The paper designs an EF-hand loop with high Ca2+ affinity using machine learning and validates it through mutagenesis, ITC, and crystallography, showing enhanced binding and altered oligomerization.

bioRxiv · Oct 4, 2021Biophysics

Queuine is a nutritional regulator of Entamoeba histolytica response to oxidative stress and a virulence attenuator

S. Nagaraja, M. W. Cai, J. Sun, H. Varet, L. Sarid, Y. Shaulov, M. Trebicz-Geffen, M. Mazumdar, R. Legendre, J.-Y. Coppee, T. Begley, P. C. Dedon, S. Gourinath, N. Guillen, Y. Saito-Nakano, , S. Ankri

This study shows queuine, a gut bacterial product, enhances Entamoeba histolytica's oxidative stress resistance while reducing its virulence by modifying tRNAs and altering gene expression.

bioRxiv · Apr 30, 2020Microbiology