Addition of a carboxy terminal tail to the normally tailless gonadotropin-releasing hormone receptor impairs fertility in female mice
C. Toufaily, J. Fortin, C. A. I. Alonso, E. Lapointe, X. Zhou, Y. Santiago-Andres, Y.-F. Lin, Y. Cui, Y. Wang, D. Devost, F. Roelfsema, F. Steyn, A. C. Hanyaloglu, T. Hebert, T. Fiordelisio, , D. J. Bernard
This study shows that adding a C-terminal tail to the tailless murine GnRHR impairs fertility by reducing FSH production and ovarian follicle development.
bioRxiv · Sep 13, 2021Physiology