Author

C. V. Nicchitta

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

Q. Chen· 2 shared A. Barrera· 1 shared A. M. Hoffman· 1 shared D. W. Reid· 1 shared H. X. Ang· 1 shared I. C. McDowell· 1 shared J. Lin· 1 shared J. R. Child· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

Q. Chen

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Author profile →

3 papers

Recent·Most cited

Selective recruitment of endoplasmic reticulum-targeted and cytosolic mRNAs into membrane-associated stress granules

J. R. Child, Q. Chen, D. W. Reid, S. Jagannathan, C. V. Nicchitta

This study identifies that ER-targeted mRNAs can be recruited into stress granules during the UPR and shows that transcriptional state influences SG formation.

bioRxiv · May 12, 2021Cell Biology

Cooperative regulation of coupled oncoprotein translation and stability in triple-negative breast cancer by EGFR and CDK12

H. X. Ang, N. Sutiman, X. L. Deng, L. C. Bartelt, Q. Chen, A. Barrera, J. Lin, J. Z. Sheng, I. C. McDowell, T. E. Reddy, C. V. Nicchitta, K. C. Wood

The paper identifies CDK12 inhibition as a strategy to enhance EGFR blockade efficacy in TNBC by targeting translation and stability of oncoproteins like MYC through 4E-BP1 and CCR4-NOT complex.

bioRxiv · Mar 3, 2021 · PreprintCancer Biology

Quantitative proteomics links the LRRC59 interactome to mRNA translation on the ER membrane

M. M. Hannigan, A. M. Hoffman, J. W. Thompson, T. Zheng, C. V. Nicchitta

The paper identifies the interactomes of ER ribosome-binding proteins, revealing distinct molecular environments and functional roles for SEC62 and LRRC59 in ER redox regulation and mRNA translation.

bioRxiv · Mar 4, 2020Cell Biology