Author

J. W. Thompson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:development & morphogenesis· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

L. Wang· 2 shared A. Bitto· 1 shared A. J. Rush· 1 shared A. L. Antonia· 1 shared A. L. Schacht· 1 shared A. M. Hoffman· 1 shared A. Moradian· 1 shared A. S. Grillo· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersBiochemistry

L. Wang

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Author profile →

6 papers

Recent·Most cited

Functional glycoproteomics by integrated network assembly and partitioning

M. E. Griffin, J. W. Thompson, Y. Xiao, M. J. Sweredoski, E. H. Jensen, Y. Koldobskaya, A. L. Schacht, T. D. Kim, P. Choudhry, B. Lomenick, S. D. Garbis, A. Moradian, L. C. Hsieh-Wilson

This paper introduces a systems-level approach to study O-GlcNAcylation by integrating AP-MS and chemoproteomics with network analysis, revealing both conserved and tissue-specific functions.

bioRxiv · Jun 13, 2023 · PreprintCell Biology

Acarbose suppresses symptoms of mitochondrial disease in a mouse model of Leigh Syndrome

A. Bitto, A. S. Grillo, I. B. Stanaway, B. M. G. Nguyen, K. Ying, H. Tung, K. Smith, N. Tran, G. Velikanje, S. Urfer, J. M. Snyder, E.-B. Kayser, L. Wang, D. L. Smith, J. W. Thompson, , M. Kaeberlein

This study shows acarbose reduces symptoms and improves survival in a mouse model of Leigh Syndrome, independent of mTOR inhibition, and suggests gut microbiome modulation may impact mitochondrial disease.

bioRxiv · Jan 31, 2022 · PreprintBiochemistry

Centrosomal Enrichment and Proteasomal Degradation of SYS-1/-β-catenin Requires the Microtubule Motor Dynein

J. W. Thompson, M. F. Valdes Michel, B. T. Phillips

This study shows that dynein-mediated trafficking is required for SYS-1 centrosomal enrichment and proteasomal degradation in C. elegans.

bioRxiv · Nov 10, 2021Cell Biology

Quantitative proteomics links the LRRC59 interactome to mRNA translation on the ER membrane

M. M. Hannigan, A. M. Hoffman, J. W. Thompson, T. Zheng, C. V. Nicchitta

The paper identifies the interactomes of ER ribosome-binding proteins, revealing distinct molecular environments and functional roles for SEC62 and LRRC59 in ER redox regulation and mRNA translation.

bioRxiv · Mar 4, 2020Cell Biology

Acylcarnitine Metabolomic Profiles Inform Clinically-Defined Major Depressive Phenotypes

A. T. Ahmed, S. MahmoudianDehkordi, S. Bhattacharyya, M. Arnold, D. Liu, D. Neavin, M. A. Moseley, J. W. Thompson, L. S. J. Williams, G. Louie, M. K. Skime, L. Wang, P. Riva-Posse, W. McDonald, W. V. Bobo, , R. Kaddurah-Daouk

This study identifies distinct acylcarnitine metabolomic profiles associated with different subtypes of major depressive disorder following SSRI treatment.

bioRxiv · May 9, 2019Biochemistry

Pathogen evasion of chemokine response through suppression of CXCL10

A. L. Antonia, K. D. Gibbs, E. Trahair, K. J. Pittman, B. H. Schott, J. S. Smith, S. Rajagopal, J. W. Thompson, R. L. Reinhardt, D. C. Ko

This paper identifies a mechanism by which Leishmania major evades the immune system by cleaving CXCL10, a chemokine critical for T-cell recruitment, and shows similar strategies are used by other pathogens.

bioRxiv · Apr 29, 2019Microbiology