Self-renewal of double negative 3 (DN3) early thymocytes allows for thymus autonomy but compromises the β-selection checkpoint
R. A. Paiva, A. G. Sousa, C. V. Ramos, M. Avila, J. Lilue, T. Paixao, V. C. Martins
The paper shows DN3e thymocytes can self-renew and maintain thymopoiesis autonomously but bypass β-selection, risking leukemia.
bioRxiv · Jun 9, 2020 · PreprintImmunology