Interleukin 7 receptor drives Early T lineage Progenitor expansion
This study shows that IL-7/IL-7r signaling is essential for proliferation and survival of immature early T lineage progenitors (ETP) following thymus seeding.
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3 papers
Recent·Most cited
This study shows that IL-7/IL-7r signaling is essential for proliferation and survival of immature early T lineage progenitors (ETP) following thymus seeding.
R. A. Paiva, A. G. Sousa, C. V. Ramos…·V. C. Martins
The paper shows DN3e thymocytes can self-renew and maintain thymopoiesis autonomously but bypass β-selection, risking leukemia.
C. V. Ramos, L. Ballesteros-Arias, J. G. Silva…·V. C. Martins
The paper investigates how cell competition between DN2 and DN3e thymocytes regulates thymopoiesis and thymus cellularity through a feedback loop involving DN2b expansion and interleukin 7.