Somatic mutation of Afadin leads to anchorage independent survival and metastatic growth of breast cancer through alpha E-catenin dependent destabilization of the adherens junction
M. A. Ratze, L. N. Enserink, N. Ishiyama, C. Veldman, I. J. Nijman, R. R. Bernards, P. J. van Diest, M. Christgen, P. W. Derksen
This study identifies a somatic Afadin mutation that destabilizes adherens junctions and promotes metastatic growth in breast cancer by disrupting E-catenin binding.
bioRxiv · Jul 4, 2023 · PreprintCancer Biology