N. Ishiyama

α-catenin mechanosensitivity as a route to cytokinesis failure through sequestration of LZTS2

This study identifies α-catenin mechanosensitivity as a driver of cytokinesis failure through sequestration of LZTS2, linking it to polyploidization and retinal dystrophy.

Multiple stressors and recruitment failure of long-lived endangered freshwater mussels with a complex life cycle

This study investigates how multiple stressors affect recruitment efficiency in endangered freshwater mussels, identifying parasitic and post-parasitic juvenile stages as critical bottlenecks.

Somatic mutation of Afadin leads to anchorage independent survival and metastatic growth of breast cancer through alpha E-catenin dependent destabilization of the adherens junction

This study identifies a somatic Afadin mutation that destabilizes adherens junctions and promotes metastatic growth in breast cancer by disrupting E-catenin binding.

Recruitment status and host-fish-limitation threats to endangered freshwater pearl mussel (Margaritifera laevis) in eastern Hokkaido, northern Japan

The paper assesses recruitment status and host-fish limitation threats to endangered freshwater pearl mussels in eastern Hokkaido, finding low juvenile proportions and a positive link between juvenile presence and host-fish density.

Exploring the evolution and function of Canoes intrinsically disordered region in linking cell-cell junctions to the cytoskeleton during embryonic morphogenesis

The paper investigates the evolution and function of the intrinsically disordered region (IDR) of Canoe in linking cell-cell junctions to the cytoskeleton during Drosophila embryonic development.

The role of geology in creating stream climate-change refugia along climate gradients

This study identifies how volcanic rock-dominated watersheds create cold water refugia in mountain streams, which are more resilient to climate change than non-volcanic streams.

A strategic sampling design revealed the local genetic structure of cold-water fluvial sculpin: a focus on groundwater-dependent water temperature heterogeneity

The study reveals a genetic structure in fluvial sculpin populations influenced by groundwater-dependent temperature heterogeneity, showing asymmetric gene flow rather than temperature-driven differentiation.

EGFR Oncogenes Expressed In Glioblastoma Are Activated As Covalent Dimers And Paradoxically Stimulated By Erlotinib

The paper identifies a mechanism by which extracellular domain EGFR mutations in glioblastoma are activated through covalent dimerization, rendering ATP-site inhibitors ineffective and paradoxically promoting proliferation.