Author

R. R. Bernards

Primary ORCID profile (0000-0001-8677-3423 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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R. R. BernardsiD1 paper · The Netherlands Cancer Institute

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. F. M. Altelaar· 1 shared A. J. R. Heck· 1 shared A. Prahallad· 1 shared A. Ressa· 1 shared B. Evers· 1 shared C. Veldman· 1 shared C. Wang· 1 shared D. Gao· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperCancer Biology

A. F. M. Altelaar

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3 papers

Recent·Most cited

Somatic mutation of Afadin leads to anchorage independent survival and metastatic growth of breast cancer through alpha E-catenin dependent destabilization of the adherens junction

M. A. Ratze, L. N. Enserink, N. Ishiyama, C. Veldman, I. J. Nijman, R. R. Bernards, P. J. van Diest, M. Christgen, P. W. Derksen

This study identifies a somatic Afadin mutation that destabilizes adherens junctions and promotes metastatic growth in breast cancer by disrupting E-catenin binding.

bioRxiv · Jul 4, 2023 · PreprintCancer Biology

phospho-ERK is a response biomarker to a combination of sorafenib and MEK inhibition in liver cancer

R. R. Bernards, C. Wang, H. Jin, D. Gao, B. Evers, G. Jin, Z. Xue, L. Wang, R. Beijersbergen, W.-X. Qin

This study identifies phospho-ERK as a biomarker for response to sorafenib and MEK inhibition in liver cancer, showing synergistic effects in tumors with high phospho-ERK levels.

bioRxiv · Jan 23, 2018Cancer Biology

A system-wide approach to monitor responses to synergistic BRAF and EGFR inhibition in colorectal cancer cells

A. Ressa, E. Bosdriesz, J. de Ligt, S. Mainardi, G. Maddalo, A. Prahallad, M. Jager, L. de la Fonteijne, M. Fitzpatrick, S. Groten, A. F. M. Altelaar, R. R. Bernards, E. Cuppen, L. Wessels, A. J. R. Heck

The paper investigates molecular responses to BRAF and EGFR inhibition in colorectal cancer cells, revealing metabolic shifts and MAPK pathway reactivation.

bioRxiv · Sep 27, 2017Cancer Biology