Gain-of-function assay for SARS-CoV-2 Mpro inhibition in living cells
S. A. Moghadasi, J. T. Becker, C. Belica, C. Wick, W. L. Brown, R. Harris
The paper develops a gain-of-function assay to measure SARS-CoV-2 Mpro inhibition in living cells, using eGFP fluorescence to quantify inhibitor potency and enable high-throughput drug testing.
bioRxiv · Nov 9, 2020 · PreprintMicrobiology