Author

W. L. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

M. A. Carpenter· 2 shared R. S. Harris· 2 shared A. Z. Cheng· 1 shared C. A. Belica· 1 shared C. Belica· 1 shared C. Wick· 1 shared D. Sauter· 1 shared H. Aihara· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

M. A. Carpenter

Mutual co-authors in cluster

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3 papers

Recent·Most cited

A real-time biochemical assay for quantitative analyses of APOBEC-catalyzed DNA deamination

C. A. Belica, M. A. Carpenter, Y. Chen, W. L. Brown, N. H. Moeller, I. T. Boylan, R. S. Harris, H. Aihara

The paper develops a real-time biochemical assay to quantify APOBEC3-catalyzed DNA deamination and identify inhibitors.

bioRxiv · May 11, 2024Biochemistry

APOBEC3 degradation is the primary function of HIV-1 Vif for virus replication in the myeloid cell line THP-1

T. Ikeda, R. Shimizu, H. Nasser, M. A. Carpenter, A. Z. Cheng, W. L. Brown, D. Sauter, R. S. Harris

This study shows that HIV-1 Vif primarily degrades A3 enzymes to enable viral replication in THP-1 cells, as disrupting A3 proteins restores infectivity of Vif-deficient viruses.

bioRxiv · Mar 28, 2023 · PreprintMicrobiology

Gain-of-function assay for SARS-CoV-2 Mpro inhibition in living cells

S. A. Moghadasi, J. T. Becker, C. Belica, C. Wick, W. L. Brown, R. Harris

The paper develops a gain-of-function assay to measure SARS-CoV-2 Mpro inhibition in living cells, using eGFP fluorescence to quantify inhibitor potency and enable high-throughput drug testing.

bioRxiv · Nov 9, 2020 · PreprintMicrobiology