Author

C. Y. Leung

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:drug response / drug discovery· 2 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:optimal transport· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

J. S. Weitz· 2 shared J. Weitz· 2 shared A. Gupta· 1 shared B. K. Chan· 1 shared G. Li· 1 shared J. M. Borin· 1 shared J. R. Meyer· 1 shared L. Debarbieux· 1 shared

Activity by Year

2016-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersMicrobiology

J. S. Weitz

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Author profile →

4 papers

Recent·Most cited

Leapfrog dynamics in phage-bacteria coevolution revealed by joint analysis of cross-infection phenotypes and whole genome sequencing

A. Gupta, S. Peng, C. Y. Leung, J. M. Borin, S. J. Medina, J. Weitz, J. R. Meyer

The paper analyzes phage-bacteria coevolution using phenotypic and genomic data, finding that coevolution does not follow expected arms race dynamics but instead exhibits leapfrog dynamics.

bioRxiv · Oct 31, 2020Evolutionary Biology

Optimizing the Timing and Composition of Therapeutic Phage Cocktails: A Control-theoretic Approach

G. Li, C. Y. Leung, Y. Wardi, L. Debarbieux, J. Weitz

This study uses control-theoretic principles to optimize phage cocktail timing and composition for bacterial infection treatment, showing that two-phage cocktails can restore efficacy in immunodeficient hosts.

bioRxiv · Nov 19, 2019Microbiology

Quantitative Models of Phage-Antibiotics Combination Therapy

R. A. Rodriguez-Gonzalez, C. Y. Leung, B. K. Chan, P. E. Turner, J. S. Weitz

This study develops a nonlinear population dynamics model to evaluate phage-antibiotic combination therapy for MDR bacteria, showing improved efficacy with sub-inhibitory antibiotic concentrations and innate immune interactions.

bioRxiv · Nov 8, 2019Microbiology

Synergistic elimination of bacteria by phage and the innate immune system

C. Y. Leung, J. S. Weitz

This paper develops a model showing that phage and the innate immune system together can synergistically eliminate bacteria, which neither can achieve alone.

bioRxiv · Aug 16, 2016Microbiology