J. M. Borin

Design, optimization, and inference of biphasic decay of infectious virus particles

This paper develops methods to detect and optimize sampling for multiphasic virus decay, applying them to show that 94% of phage ΦD9 decays 16-fold faster than the remaining population.

Bacteriophage {Phi}21s receptor-binding protein evolves new functions through destabilizing mutations that generate non-genetic phenotypic heterogeneity

This study shows that bacteriophage Φ21 evolves new host receptor usage through destabilizing mutations that create non-genetic phenotypic heterogeneity in viral particles.

Rapid bacteria-phage coevolution drives the emergence of multi-scale networks

This study shows that multiscale ecological networks between Escherichia coli and bacteriophage Φ21 can emerge rapidly in lab coevolution without spatial structure.

Fecal virome transplantation is sufficient to alter fecal microbiota and drive lean and obese body phenotypes in mice

This study shows that fecal virome transplantation can alter gut microbiota and influence lean or obese body phenotypes in mice.

Comparison of bacterial suppression by phage cocktails, dual-receptor generalists, and coevolutionarily trained phages

This study compares the effectiveness of phage cocktails, dual-receptor generalists, and coevolutionarily trained phages in suppressing bacterial growth, finding that trained generalists are more effective.

Coevolutionary phage training leads to greater bacterial suppression and delays the evolution of phage resistance

This paper shows that coevolving phages with bacteria for 28 days significantly delays bacterial resistance and enhances phage suppression of growth.

Leapfrog dynamics in phage-bacteria coevolution revealed by joint analysis of cross-infection phenotypes and whole genome sequencing

The paper analyzes phage-bacteria coevolution using phenotypic and genomic data, finding that coevolution does not follow expected arms race dynamics but instead exhibits leapfrog dynamics.

De novo origin of multicellularity in response to predation

This study shows that predation can drive the evolution of multicellularity in the green alga Chlamydomonas reinhardtii, with two populations developing multicellular structures that enhance survival against the predator Paramecium tetraurelia.