BiochemistrybioRxiv
Activity-Based Ratiometric FRET Probe Reveals Oncogene-Driven Changes in Labile Copper Pools Induced by Altered Glutathione Metabolism
C. Y.-S. Chung, J. M. Posimo, S. Lee…·C. J. Chang
This paper introduces a ratiometric FRET copper probe, FCP-1, to image labile Cu(I) pools in live cells and shows oncogene-driven changes in glutathione metabolism reduce labile copper availability.
DOI 10.1073/pnas.1904610116