Author

C. J. Chang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 2 Biochemistry· 1 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Anaya-Sanchez· 1 shared A. Balakhmet· 1 shared A. Boukhatemi· 1 shared A. Chakrabarty· 1 shared A. Gupta· 1 shared A. H. Christian· 1 shared A. T. Pezacki· 1 shared B. Hann· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperMicrobiology

A. Anaya-Sanchez

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Impaired aldehyde detoxification caused by a common human polymorphism promotes anti-bacterial immunity

S. Espich, S. Berry, X. Chang, A. Balakhmet, N. T. T. Thuong, R. Dorajoo, C. C. Khor, C. K. Heng, J.-M. Yuan, W.-P. Koh, D. Fox, A. Anaya-Sanchez, L. Tenney, C. J. Chang, R. Baral, , S. A. Stanley

The paper shows ALDH2 deficiency enhances anti-bacterial immunity by increasing aldehyde levels that kill pathogens and boost inflammatory responses.

bioRxiv · Aug 24, 2023 · PreprintMicrobiology

Leishmania major-induced alteration of host cellular and systemic copper homeostasis drives the fate of infection

R. Paul, A. Chakrabarty, S. Dey, S. Samanta, R. Pandey, S. Maji, A. T. Pezacki, C. J. Chang, R. Datta, A. Gupta

This study shows Leishmania major manipulates host copper homeostasis to evade immune responses, while macrophages use copper to kill parasites.

bioRxiv · Jul 25, 2023Cell Biology

PLEKHA5, PLEKHA6 and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis

S. Citi, S. Sluysmans, I. Mean, T. Xiao, A. Boukhatemi, F. Ferreira, L. Jond, C. J. Chang

bioRxiv · Jun 17, 2021Cell Biology

Systematic identification of engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugation

S. K. Elledge, H. L. Tran, A. H. Christian, V. Steri, B. Hann, F. D. Toste, C. J. Chang, J. A. Wells

This study systematically identifies engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugation, finding stable sulfimide modifications comparable to cysteine-maleimide conjugation.

bioRxiv · Aug 28, 2019Bioengineering

Activity-Based Ratiometric FRET Probe Reveals Oncogene-Driven Changes in Labile Copper Pools Induced by Altered Glutathione Metabolism

C. Y.-S. Chung, J. M. Posimo, S. Lee, T. Tsang, J. M. Davis, D. C. Brady, C. J. Chang

This paper introduces a ratiometric FRET copper probe, FCP-1, to image labile Cu(I) pools in live cells and shows oncogene-driven changes in glutathione metabolism reduce labile copper availability.

bioRxiv · Jun 24, 2019Biochemistry