Enteroviral 2C protein is an RNA-stimulated ATPase and uses a two-step mechanism for binding to RNA and ATP
C. Yeager, G. Carter, D. W. Gohara, N. H. Yennawar, E. J. Enemark, J. J. Arnold, C. E. Cameron
This study elucidates the biochemical mechanism of enteroviral 2C protein's ATPase activity, showing RNA stimulates ATP hydrolysis via a two-step binding mechanism.
bioRxiv · Sep 28, 2022Biochemistry