Y. Hara

Sustaining microglial reparative function enhances stroke recovery

This study identifies ZFP384 as a regulator that impairs microglial reparative function after stroke, and shows that targeting ZFP384 enhances recovery even in the chronic phase.

Dystroglycan N-terminal domain enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy

This study shows that the N-terminal domain of dystroglycan is required for LARGE1 to extend matriglycan to its full length, preventing muscular dystrophy.

A novel fluorescently-labeled long-chain fatty acid analog for the study of fatty acid metabolism in cultured cells

This paper develops a fluorescent BMIPP analog to study long-chain fatty acid metabolism in cultured cells, showing it is transported via CD36 and reflects LCFA dynamics.

Gene fate spectrum as a reflection of local genomic properties

The paper identifies elusive genes lost in multiple mammalian lineages and links their loss to ancient genomic features like high mutation rates and gene density.

Piezo1 activation using Yoda1 inhibits macropinocytosis and proliferation of cancer cells

The paper shows Yoda1 inhibits macropinocytosis and cancer cell proliferation by activating Piezo1, which regulates Ca2+ influx and KCa3.1 channel activity.

The mechanosensitive Ca2+-permeable ion channel PIEZO1 promotes satellite cell function in skeletal muscle regeneration

This study shows that PIEZO1, a mechanosensitive ion channel, promotes satellite cell function and skeletal muscle regeneration by mediating calcium influx and RhoA-mediated actomyosin formation.

Hijacking of Multiple Phospholipid Biosynthetic Pathways and Induction of Membrane Biogenesis by a Picornaviral 3CD Protein

This paper shows that a picornaviral 3CD protein induces multiple phospholipid biosynthetic pathways and membrane biogenesis by hijacking cellular machinery.