Keratins couple with the nuclear lamina and regulate proliferation in colonic epithelial cells
C.-G. A. Stenvall, J. H. Nyström, C. Butler-Hallissey, S. A. Adam, R. Foisner, K. M. Ridge, R. D. Goldman, D. M. Toivola
This study shows that keratin 8 (K8) in colonic epithelial cells couples with the nuclear lamina, regulates proliferation through pRb and YAP, and its loss leads to hyperproliferation and reduced lamins.
bioRxiv · Jun 22, 2020Cell Biology