S. A. Adam

Delayed localization of A-type lamins to the rupture sites in Hutchinson-Gilford progeria syndrome

This study investigates the delayed localization of A-type lamins to nuclear envelope rupture sites in HGPS, identifying farnesylation and proteolytic cleavage as key factors affecting this process.

Vimentin Intermediate Filaments and Filamentous Actin Form Unexpected Interpenetrating Networks That Redefine the Cell Cortex

This study reveals that vimentin intermediate filaments and F-actin form an interpenetrating network in the cell cortex, enhancing contractile forces and influencing actin dynamics.

Nucleoplasmic Lamin C Rapidly Accumulates at Sites of Nuclear Envelope Rupture with BAF and cGAS

The paper shows lamin C, BAF, and cGAS accumulate at nuclear envelope rupture sites in mouse cells, with lamin A/C involvement in DNA sensing.

Nuclear lamin isoforms differentially contribute to LINC complex-dependent nucleocytoskeletal coupling and whole cell mechanics

This study shows that different nuclear lamin isoforms modulate cell and nuclear mechanics by affecting LINC complex stability and heterochromatin structure in mouse embryonic fibroblasts.

Keratins couple with the nuclear lamina and regulate proliferation in colonic epithelial cells

This study shows that keratin 8 (K8) in colonic epithelial cells couples with the nuclear lamina, regulates proliferation through pRb and YAP, and its loss leads to hyperproliferation and reduced lamins.

Computational analysis of lamin isoform interactions with nuclear pore complexes

The paper analyzes lamin isoform interactions with nuclear pore complexes using microscopy data from mouse fibroblasts, showing their role in maintaining nuclear envelope organization.

The versatility of Ascorbate Peroxidase-aided mapping uncovers insights of thenuclear lamina interactions and function

This paper introduces an APEX2-based method to map proteins, RNA, and DNA associated with the nuclear lamina, revealing new insights into its regulatory roles and dynamic interactions.

Vimentin protects the structural integrity of the nucleus and suppresses nuclear damage caused by large deformations

This study shows that vimentin intermediate filaments protect the nucleus from damage during cell migration by maintaining its shape and mechanical integrity.

Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation

This study shows that extracellular cations alter nuclear shape and mechanics through heterochromatin formation, rescuing nuclear morphology in disease models.

Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins

The paper shows that chromatin histone modifications affect nuclear rigidity and morphology independently of lamins, inducing or suppressing nuclear blebs through changes in chromatin compaction.