R. D. Goldman

Delayed localization of A-type lamins to the rupture sites in Hutchinson-Gilford progeria syndrome

This study investigates the delayed localization of A-type lamins to nuclear envelope rupture sites in HGPS, identifying farnesylation and proteolytic cleavage as key factors affecting this process.

Vimentin filaments integrate low complexity domains in a highly complex helical structure

This study determines the 3D structure of vimentin intermediate filaments, revealing how disordered domains contribute to their mechanical properties.

Nucleoplasmic Lamin C Rapidly Accumulates at Sites of Nuclear Envelope Rupture with BAF and cGAS

The paper shows lamin C, BAF, and cGAS accumulate at nuclear envelope rupture sites in mouse cells, with lamin A/C involvement in DNA sensing.

The molecular architecture of vimentin filaments

This study reveals the subnanometer structure of vimentin filaments in mouse cells, showing their helical symmetry and molecular composition.

Nuclear lamin isoforms differentially contribute to LINC complex-dependent nucleocytoskeletal coupling and whole cell mechanics

This study shows that different nuclear lamin isoforms modulate cell and nuclear mechanics by affecting LINC complex stability and heterochromatin structure in mouse embryonic fibroblasts.

Structural heterogeneity of cellular K5/K14 filaments as revealed by cryo-electron microscopy

This study uses cryo-electron microscopy to reveal the structural heterogeneity of keratin 5/keratin 14 filaments, showing variations in diameter and subunit organization.

Keratins couple with the nuclear lamina and regulate proliferation in colonic epithelial cells

This study shows that keratin 8 (K8) in colonic epithelial cells couples with the nuclear lamina, regulates proliferation through pRb and YAP, and its loss leads to hyperproliferation and reduced lamins.

Computational analysis of lamin isoform interactions with nuclear pore complexes

The paper analyzes lamin isoform interactions with nuclear pore complexes using microscopy data from mouse fibroblasts, showing their role in maintaining nuclear envelope organization.

The versatility of Ascorbate Peroxidase-aided mapping uncovers insights of thenuclear lamina interactions and function

This paper introduces an APEX2-based method to map proteins, RNA, and DNA associated with the nuclear lamina, revealing new insights into its regulatory roles and dynamic interactions.

Effect of the divalent cations zinc and calcium on the structure and mechanics of reconstituted vimentin intermediate filaments

This study examines how zinc and calcium ions affect the structure and mechanics of vimentin intermediate filaments, showing that zinc is more effective at lower concentrations and that ion binding can compete.

High stretchability, strength and toughness of living cells enabled by hyperelastic vimentin network

This study shows that vimentin intermediate filaments provide cytoplasmic mechanics that enhance strength, stretchability, resilience, and toughness under severe deformations.

Probe Sensitivity to Cortical versus Intracellular Cytoskeletal Network Stiffness

The paper compares the sensitivity of four probe technologies to measure biomechanical properties of different cellular regions in two cell types under various perturbations.

Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation

This study shows that extracellular cations alter nuclear shape and mechanics through heterochromatin formation, rescuing nuclear morphology in disease models.