HIV Envelope Trimer-Elicited Autologous Neutralizing Antibodies Bind a Region Overlapping the N332 Glycan Supersite
B. Nogal, L. E. McCoy, M. J. van Gils, C. A. Cottrell, J. E. Voss, R. Andrabi, M. G. Pauthner, C.-H. Liang, T. Messmer, R. Nedellec, M. Shin, H. L. Turner, G. Ozorowski, R. W. Sanders, D. Burton, A. B. Ward
The paper identifies monoclonal antibodies from rabbits that bind an epitope overlapping the N332 glycan supersite but not the glycan hole, suggesting strain-specific responses may interfere with broadly neutralizing antibodies.
bioRxiv · Nov 5, 2019Immunology