Author

C.-I. Chung

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

X. Shu· 2 shared A. Navalkar· 1 shared D. Lu· 1 shared F. Bai· 1 shared F. Li· 1 shared H. Liu· 1 shared J. A. Woyach· 1 shared J. Chen· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

X. Shu

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2 papers

Recent·Most cited

Phase separation of Myc differentially regulates gene transcription

J. Yang, C.-I. Chung, J. Koach, H. Liu, A. Navalkar, Z. Ma, Q. Zhao, X. Yang, T. Mittag, Y. Shen, W. A. Weiss, X. Shu

The paper investigates how phase separation of N-myc affects gene transcription and finds that only a small fraction of N-myc-regulated genes are influenced by this process.

bioRxiv · Jun 28, 2022 · PreprintCell Biology

Enhancing Intracellular Accumulation and Target Engagement of PROTACs with Reversible Covalent Chemistry

W.-H. Guo, X. Qi, X. Yu, Y. Liu, C.-I. Chung, F. Bai, X. Lin, D. Lu, L. Wang, J. Chen, L. Su, K. J. Nomie, F. Li, M. C. Wang, X. Shu, , J. Wang

This study discovers that reversible covalent chemistry enhances PROTAC intracellular accumulation and target engagement, leading to improved efficacy.

bioRxiv · Dec 30, 2019Pharmacology & Toxicology