Author

W. A. Weiss

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 5 Research Focus:cancer & tumor microenvironment· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

W. Wu· 2 shared A. Banuelos· 1 shared A. Barkal· 1 shared A. Carlson· 1 shared A. Delaidelli· 1 shared A. Dupuy· 1 shared A. G. Rust· 1 shared A. Grossman· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersImmunology

W. Wu

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

PRDM6 promotes medulloblastoma by repressing chromatin accessibility and altering gene expression

C. Schmidt, S. Cohen, B. L. Gudenas, S. Husain, A. Carlson, S. Westelman, L. Wang, J. J. Phillips, P. A. Northcott, W. A. Weiss, B. Schwer

This study shows PRDM6 represses chromatin accessibility and alters gene expression in neuroepithelial stem cells, promoting medulloblastoma but not sufficient to drive Group 4 medulloblastoma alone.

bioRxiv · Aug 29, 2023 · PreprintCancer Biology

Phase separation of Myc differentially regulates gene transcription

J. Yang, C.-I. Chung, J. Koach, H. Liu, A. Navalkar, Z. Ma, Q. Zhao, X. Yang, T. Mittag, Y. Shen, W. A. Weiss, X. Shu

The paper investigates how phase separation of N-myc affects gene transcription and finds that only a small fraction of N-myc-regulated genes are influenced by this process.

bioRxiv · Jun 28, 2022 · PreprintCell Biology

"Transposon Mutagenesis Reveals RBMS3 as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis."

A. Vaishnavi, J. Juan, M. T. Scherzer, J. E. VanVeen, C. Stehn, C. S. Hackett, A. Dupuy, S. A. Chmura, L. van der Weyden, J. Y. Newberg, K. M. Mann, A. Liu, A. G. Rust, W. A. Weiss, D. Adams, , M. McMahon

This paper identifies RBMS3 as a tumor suppressor that cooperates with BRAFV600E to promote malignant lung cancer progression using transposon mutagenesis and CRISPR validation.

bioRxiv · Feb 28, 2022 · PreprintCancer Biology

Anti-GD2 antibody disrupts GD2:Siglec-7 interactions and synergizes with CD47 blockade to mediate tumor eradication

J. Theruvath, M. Menard, B. A. Smith, M. H. Linde, G. Coles, W. Wu, L. Kiru, A. Delaidelli, J. L. Silberstein, A. Banuelos, S. Dhingra, E. Sotillo, S. Heitzeneder, A. Tousley, J. Lattin, , R. G. Majzner

This study shows that combining anti-GD2 and anti-CD47 antibodies enhances anti-tumor responses by recruiting macrophages and disrupting the GD2:Siglec-7 interaction in GD2+ cancers.

bioRxiv · Mar 19, 2021 · PreprintImmunology

Deep immune profiling reveals targetable mechanisms of immune evasion in checkpoint blockade-refractory glioblastoma

E. F. Simonds, E. D. Lu, E. V. Liu, W. Tamaki, C. Rancan, J. Stultz, M. Sinha, L. K. McHenry, N. M. Nasholm, P. Chuntova, A. Sundstrom, V. Genoud, S. A. Shahani, L. D. Wang, c. brown, , M. Hellstrom

This study identifies immune evasion mechanisms in checkpoint blockade-refractory glioblastoma using deep immune profiling and shows that enhancing antigen presentation can improve immunotherapy response.

bioRxiv · Dec 1, 2020Cancer Biology

Brain-Restricted mTOR Inhibition with Binary Pharmacology

Z. Zhang, Q. Fan, X. Luo, K. J. Lou, W. A. Weiss, K. Shokat

This paper describes a strategy to achieve brain-restricted mTOR inhibition using a combination of a brain-permeable inhibitor and a brain-impermeable ligand, while preserving systemic mTOR activity.

bioRxiv · Oct 12, 2020Cancer Biology

Synthetic essentiality of metabolic regulator PDHK1 in PTEN-deficient cells and cancers

N. Chatterjee, E. Pazarentzos, G. Hrustanovic, L. Lin, E. Verschueren, J. R. Johnson, M. Hofree, J. J. Yan, V. Olivas, B. W. Newton, J. V. Dollen, C. H. Earnshaw, J. Flanagan, E. Chan, S. Asthana, , T. G. Bivona

The paper identifies PDHK1 as a synthetic-essential gene in PTEN-deficient cells and cancers, showing its upregulation drives aerobic glycolysis and correlates with poor patient survival.

bioRxiv · Oct 11, 2018Cancer Biology