Intramembrane protease RHBDL4 cleaves oligosaccharyltransferase subunits to target them for ER-associated degradation
J. D. Knopf, N. Landscheidt, C. L. Pegg, B. L. Schulz, N. Kuehnle, C.-W. Chao, S. Huck, M. K. Lemberg
This study identifies RHBDL4 as a regulator of the oligosaccharyltransferase complex through ERAD-mediated degradation, revealing a novel link between ERAD and glycosylation regulation.
bioRxiv · Jan 19, 2020Cell Biology