Author

C. L. Pegg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 9 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 10 Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Organism:human· 4 Research Focus:protein folding & dynamics· 3 Approach:statistical model· 3 Approach:deep learning· 2 Approach:benchmark study· 1

Frequent Co-Authors

B. L. Schulz· 10 shared T. K. Phung· 6 shared L. F. Zacchi· 4 shared C. B. Howard· 3 shared A. S. Nouwens· 2 shared C. H. Caboche· 2 shared D. Roche Recinos· 2 shared E. D. Kerr· 2 shared

Activity by Year

2020-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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10 shared papersBiochemistry

B. L. Schulz

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Author profile →

10 papers

Recent·Most cited

Electron-Activated Dissociation and Collision-Induced Dissociation Glycopeptide Fragmentation for Improved Glycoproteomics

K. L. Macauslane, C. L. Pegg, A. S. Nouwens, E. D. Kerr, J. Seitanidou, B. L. Schulz

This study compares fragmentation methods for glycopeptide analysis, finding CID identifies more glycopeptides while EAD improves site localization, and EAciD combines both benefits.

bioRxiv · Feb 22, 2024Biochemistry

The role of N-glycosylation in spike antigenicity for the SARS-CoV-2 Gamma variant

C. L. Pegg, N. Modhiran, R. Parry, B. Liang, A. A. Amarilla, A. Khromykh, L. Burr, P. Young, K. Chappell, B. L. Schulz, D. Watterson

This study compares glycosylation and antigenicity of SARS-CoV-2 Wu-1 and Gamma variants, finding that an NTD mutation alters glycan site occupancy but not antibody binding.

bioRxiv · Apr 3, 2023 · PreprintBiochemistry

Community Evaluation of Glycoproteomics Informatics Solutions Reveals High-Performance Search Strategies of Serum N- and O-Glycopeptide Data

R. Kawahara, A. Chernykh, K. Alagesan, M. Bern, W. Cao, R. J. Chalkley, K. Cheng, M. S. Choo, N. Edwards, R. Goldman, M. Hoffmann, Y. Hu, Y. Huang, J. Y. Kim, D. Kletter, , Palmisano

This study evaluates glycoproteomics software performance using human serum datasets, identifies high-performance strategies, and provides recommendations for improved analysis.

bioRxiv · Mar 14, 2021 · PreprintBiochemistry

N-glycosylation on Oryza Sativa Root Germin-like Protein 1 is conserved but not required for stability or activity

T. Rubbab, C. L. Pegg, T. K. Phung, A. S. Nouwens, B. K. Y. Yeo, L. F. Zacchi, A. Muhammad, S. M. S. S. Naqvi, B. L. Schulz

This study shows that N-glycosylation on OsRGLP1 is conserved but not required for stability or activity, and describes a method for its efficient production in E. coli.

bioRxiv · Feb 9, 2021Biochemistry

The post-translational modification landscape of commercial beers

E. D. Kerr, C. H. Caboche, C. L. Pegg, T. K. Phung, C. Gonzalez Viejo, S. Fuentes, M. T. Howes, K. Howell, B. L. Schulz

This study analyzes the post-translational modification landscape of 23 commercial Australian beers using DIA/SWATH-MS, revealing high diversity in PTMs and brewery-specific glyco/proteome profiles.

bioRxiv · Jan 27, 2021Biochemistry

Quantitative data independent acquisition glycoproteomics of sparkling wine

C. L. Pegg, T. K. Phung, C. H. Caboche, S. Niamsuphap, M. Bern, K. Howell, B. L. Schulz

This study quantitatively analyzes glycoproteomics in sparkling wines to assess aging and yeast strain effects on glycosylation profiles.

bioRxiv · Jun 9, 2020Biochemistry

Analysis of coagulation factor IX in bioreactor cell culture medium predicts yield and quality of the purified product

L. F. Zacchi, D. Roche Recinos, C. L. Pegg, T. K. Phung, M. Napoli, C. Aitken, V. Sandford, S. M. Mahler, Y. Y. Lee, B. L. Schulz, C. B. Howard

The paper uses DIA-MS proteomics to predict rFIX yield and quality by analyzing bioreactor supernatant, identifying PTMs and their impact on purification and function.

bioRxiv · Jun 3, 2020Biochemistry

Identification of novel glycosylation events on human serum-derived Factor IX

C. L. Pegg, L. F. Zacchi, D. Roche Recinos, C. B. Howard, B. L. Schulz

The paper identifies two novel glycosylation sites on human Factor IX, including an O-linked site at serine 141 and an N-linked site at asparagine 258, contributing to structural characterization for therapeutic development.

bioRxiv · Mar 6, 2020Biochemistry

Glycoproteomic measurement of site-specific polysialylation

R. Pelingon, C. L. Pegg, L. F. Zacchi, T. K. Phung, C. B. Howard, P. Xu, M. P. Hardy, C. M. Owczarek, B. L. Schulz

This paper develops a high-throughput glycoproteomics method to measure site-specific polysialylation using LC-ESI-MS/MS after mild acid hydrolysis and desialylation.

bioRxiv · Jan 21, 2020Biochemistry

Intramembrane protease RHBDL4 cleaves oligosaccharyltransferase subunits to target them for ER-associated degradation

J. D. Knopf, N. Landscheidt, C. L. Pegg, B. L. Schulz, N. Kuehnle, C.-W. Chao, S. Huck, M. K. Lemberg

This study identifies RHBDL4 as a regulator of the oligosaccharyltransferase complex through ERAD-mediated degradation, revealing a novel link between ERAD and glycosylation regulation.

bioRxiv · Jan 19, 2020Cell Biology