Author

N. Kuehnle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

J. D. Knopf· 2 shared M. K. Lemberg· 2 shared N. Landscheidt· 2 shared B. L. Schulz· 1 shared C. L. Pegg· 1 shared C.-W. Chao· 1 shared E. Gottwein· 1 shared J. Bock· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCell Biology

J. D. Knopf

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

CRISPR Screens Identify Novel Regulators of cFLIP Dependency and Ligand-Independent, TRAIL-R1-Mediated Cell Death

N. Kuehnle, S. M. Osborne, Z. Liang, M. Manzano, E. Gottwein

The paper identifies novel regulators of cFLIP dependency and ligand-independent TRAIL-R1-mediated cell death in PEL cells using CRISPR screens and functional experiments.

bioRxiv · Aug 17, 2022Microbiology

Rhomboid protease RHBDL4 promotes retrotranslocation of aggregation-prone proteins for degradation

J. Bock, N. Kuehnle, J. D. Knopf, N. Landscheidt, J.-G. Lee, Y. Ye, M. K. Lemberg

This study identifies RHBDL4 as a rhomboid protease that promotes retrotranslocation of aggregation-prone proteins for degradation, working with the erlin ERAD complex.

bioRxiv · Dec 17, 2021Cell Biology

Intramembrane protease RHBDL4 cleaves oligosaccharyltransferase subunits to target them for ER-associated degradation

J. D. Knopf, N. Landscheidt, C. L. Pegg, B. L. Schulz, N. Kuehnle, C.-W. Chao, S. Huck, M. K. Lemberg

This study identifies RHBDL4 as a regulator of the oligosaccharyltransferase complex through ERAD-mediated degradation, revealing a novel link between ERAD and glycosylation regulation.

bioRxiv · Jan 19, 2020Cell Biology