Author

J. D. Knopf

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

M. K. Lemberg· 3 shared N. Kuehnle· 2 shared N. Landscheidt· 2 shared B. Buchmuller· 1 shared B. Kurtulmus· 1 shared B. L. Schulz· 1 shared C. L. Pegg· 1 shared C.-W. Chao· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCell Biology

M. K. Lemberg

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3 papers

Recent·Most cited

Rhomboid protease RHBDL4 promotes retrotranslocation of aggregation-prone proteins for degradation

J. Bock, N. Kuehnle, J. D. Knopf, N. Landscheidt, J.-G. Lee, Y. Ye, M. K. Lemberg

This study identifies RHBDL4 as a rhomboid protease that promotes retrotranslocation of aggregation-prone proteins for degradation, working with the erlin ERAD complex.

bioRxiv · Dec 17, 2021Cell Biology

CRISPR-Cas12a-assisted PCR tagging of mammalian genes

J. Fueller, K. Herbst, M. Meurer, K. Gubicza, B. Kurtulmus, J. D. Knopf, D. Kirrmaier, B. Buchmuller, G. Pereira, M. K. Lemberg, M. Knop

This paper describes a method for efficient endogenous gene tagging in mammalian cells using CRISPR-Cas12a and PCR cassettes, achieving up to 60% tagging efficiency with selection.

Journal of Cell Biology · May 13, 2020Peer-reviewedCell Biology

Intramembrane protease RHBDL4 cleaves oligosaccharyltransferase subunits to target them for ER-associated degradation

J. D. Knopf, N. Landscheidt, C. L. Pegg, B. L. Schulz, N. Kuehnle, C.-W. Chao, S. Huck, M. K. Lemberg

This study identifies RHBDL4 as a regulator of the oligosaccharyltransferase complex through ERAD-mediated degradation, revealing a novel link between ERAD and glycosylation regulation.

bioRxiv · Jan 19, 2020Cell Biology