A Sensitized ENU Mutagenesis Screen for Thrombosis Modifiers Identifies Suppressor Variants in Non-mutagenized Parental Generations Due to Antithrombotic Selective Pressures
Marisa A Brake, Audrey C. A. Cleuren, Sydney J. Torres, Martijn A. van der Ent, Guojing Zhu, Justin R. Kulchycki, Tyler M. Parsons, Caitlin D. Schneider, Adrianna M. Jurek, Kailey H MacFadyen, Amy E. Siebert, David R. Siemieniak, Andrew E. Timms, David R. Beier, Randal Joseph Westrick
The paper identifies four spontaneous mutations that confer survival in a thrombosis model by reducing platelet aggregation and altering gene expression.
bioRxiv · Jan 25, 2026 · PreprintGenetics