Audrey C. A. Cleuren

This study shows that endothelial origin, not inflammatory stimulus, primarily determines transcriptional and functional responses to LPS and IL-6/IL-6R.

The paper identifies a GATA2-PROX1-FOXC2 regulatory axis that integrates shear stress signaling with lymphatic vascular development, showing dosage-dependent cooperation between GATA2 and FOXC2.

The paper identifies four spontaneous mutations that confer survival in a thrombosis model by reducing platelet aggregation and altering gene expression.

This study examines how LPS and Shiga toxin exposure affect gene expression in endothelial cells, finding synergistic effects at 24 hours.

This study investigates the role of protease-activated receptors 1 and 4 on hepatic endothelial cells during acetaminophen overdose, finding that low-expressing PAR4 is a potent receptor with functional redundancy to PAR1.

The paper uses EC-TRAP to analyze endothelial cell translatomes across vascular beds, revealing heterogeneity in gene expression and improved detection of low-abundance transcripts.

The paper identifies a de novo mutation in Plcb4 that suppresses thrombosis in mice with Factor V Leiden and tissue factor pathway inhibitor mutations.

This study shows that SEC24D can functionally substitute for SEC24C in mice, as Sec24cc-d/c-d pups survive to term despite embryonic lethality in Sec24c null mice.

The paper identifies novel thrombosis suppressor loci using a sensitized mutagenesis screen in Factor V Leiden mice, finding F8 and the Tfpi/F3 axis, as well as Actr2, play key roles in thrombosis regulation.