Tyler M. Parsons

JARID2 inhibition enhances repopulating activity of human hematopoietic stem and progenitor cells in vivo via STAT1 upregulation.

The paper identifies four spontaneous mutations that confer survival in a thrombosis model by reducing platelet aggregation and altering gene expression.

This study shows that leukemic clones can evolve independently of JAK2V617F in MPNs and contribute to disease progression through pro-inflammatory environments.