Marisa A Brake

POmAb, an antibody targeting open prothrombin, results in anticoagulation without excessive bleeding in mice

This study evaluates POmAb, an anti-prothrombin antibody, in mice showing it reduces thrombin generation and fibrin formation without excessive bleeding.

A Sensitized ENU Mutagenesis Screen for Thrombosis Modifiers Identifies Suppressor Variants in Non-mutagenized Parental Generations Due to Antithrombotic Selective Pressures

The paper identifies four spontaneous mutations that confer survival in a thrombosis model by reducing platelet aggregation and altering gene expression.

Identification of Regulatory Loci for Megakaryocyte and Hepatocyte Coagulation Factor V Expression in Mice

The paper identifies genomic loci regulating Factor V expression in hepatocytes and megakaryocytes of mice using QTL analysis across multiple strains.

A sensitized mutagenesis screen in Factor V Leiden mice identifies novel thrombosis suppressor loci

The paper identifies novel thrombosis suppressor loci using a sensitized mutagenesis screen in Factor V Leiden mice, finding F8 and the Tfpi/F3 axis, as well as Actr2, play key roles in thrombosis regulation.