Martijn A. van der Ent

This study shows that endothelial origin, not inflammatory stimulus, primarily determines transcriptional and functional responses to LPS and IL-6/IL-6R.

The paper identifies a GATA2-PROX1-FOXC2 regulatory axis that integrates shear stress signaling with lymphatic vascular development, showing dosage-dependent cooperation between GATA2 and FOXC2.

The paper identifies four spontaneous mutations that confer survival in a thrombosis model by reducing platelet aggregation and altering gene expression.

The paper identifies genetic variants in RASA1 and EPHB4 associated with vein of Galen malformations through exome analysis and single-cell transcriptomics.

The paper uses EC-TRAP to analyze endothelial cell translatomes across vascular beds, revealing heterogeneity in gene expression and improved detection of low-abundance transcripts.

This study shows that SEC24D can functionally substitute for SEC24C in mice, as Sec24cc-d/c-d pups survive to term despite embryonic lethality in Sec24c null mice.

This study compares the epigenomes of neutrophils and monocytes to identify regulatory elements and chromatin states, revealing differences in enhancer activity and DNA methylation.