Author

Caitlin Lahue

University of North Carolina at Chapel Hill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Genomics· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 5 Organism:mouse· 5 Approach:statistical model· 5 Assay:bulk RNA-seq· 4 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Christoph D. RauiD· 5 shared Aryan DalaliD· 3 shared Sriram RavindraniD· 3 shared Brian GuraliD· 2 shared Todd Haswell KimballiD· 2 shared Abigail Hockett· 1 shared Alexandra L. PurdyiD· 1 shared Amira Ali· 1 shared

Activity by Year

2023-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersGenomics

Christoph D. RauORCID

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5 papers

Recent·Most cited

Genetic Determinants of Heart Failure Susceptibility and Response in the Collaborative Cross Mouse Population

Todd Haswell Kimball, Anh N. Luu, Brian Gural, Caitlin Lahue, Abigail Hockett, Sriram Ravindran, Amira Ali, Aryan Dalal, Sam Ardery, Emily L. Sipko, Logan G. Kirkland, Mansi Goyal, Brian C. Jensen, Rebecca B. Berlow, Christoph D Rau

The paper identifies genetic loci associated with heart failure susceptibility and response in mice, highlighting candidate genes that modulate cardiac hypertrophy.

Genetics · Jan 30, 2026Peer-reviewedGenomics

A systems genetics approach to uncover mitochondrial drivers of heart failure reveals mitochondria-nuclear cross talk in genetically diverse mouse strains

Sriram Ravindran, Todd Haswell Kimball, Brian Gural, Caitlin Lahue, Christoph D Rau

The paper uses systems genetics in genetically diverse mice to identify mitochondrial-nuclear interactions contributing to heart failure, finding 24 gene candidates associated with mt-DNA and HF.

bioRxiv · Dec 15, 2025 · PreprintGenetics

Global Analyses of Genomic and Epigenomic Influences on Gene Expression Reveals Serpina3n as a Major Regulator of Cardiac Gene Expression in Response to Catecholamine Challenge During Heart Failure

Caitlin Lahue, Sriram Ravindran, Aryan Dalal, Rozeta Avetisyan, Christoph D Rau

The paper identifies Serpina3n as a major regulator of cardiac gene expression in heart failure by integrating genetic and epigenetic data from mouse strains.

bioRxiv · Sep 7, 2025 · PreprintGenetics

Mapping DNA Methylation to Cardiac Pathologies Induced by Beta-Adrenergic Stimulation in a Large Panel of Mice

Caitlin Lahue, Eleanor Wong, Aryan Dalal, Wilson Lek Wen Tan, Shuxun Vincent Ren, Roger Foo, Yibin Wang, Christoph D. Rau

This study identifies DNA methylation loci associated with heart failure in mice, showing their functional relevance and therapeutic potential through in vitro and in vivo experiments.

Epigenetics · Jul 7, 2025Peer-reviewedGenomics

Cardiomyocyte ploidy is dynamic during postnatal development and varies across genetic backgrounds

Samantha K. Swift, Alexandra L. Purdy, Mary E. Kolell, Michael A. Flinn, Caitlin Lahue, Tyler Buddell, Kaelin A. Akins, Parker Foster, Caitlin Claire O'Meara, Christoph D. Rau, Michaela Patterson

This study examines cardiomyocyte ploidy dynamics in two mouse strains, revealing differences in developmental progression and identifying new roles for Runx1 and Tnni3k in ploidy regulation.

Development · Mar 13, 2023Peer-reviewedDevelopmental Biology