Todd Haswell Kimball

Genetic Determinants of Heart Failure Susceptibility and Response in the Collaborative Cross Mouse Population

The paper identifies genetic loci associated with heart failure susceptibility and response in mice, highlighting candidate genes that modulate cardiac hypertrophy.

A systems genetics approach to uncover mitochondrial drivers of heart failure reveals mitochondria-nuclear cross talk in genetically diverse mouse strains

The paper uses systems genetics in genetically diverse mice to identify mitochondrial-nuclear interactions contributing to heart failure, finding 24 gene candidates associated with mt-DNA and HF.

LocusPackRat: a Semi-Automated Framework for Prioritizing Candidate Genes from Large GWAS Intervals

LocusPackRat streamlines candidate gene prioritization from GWAS intervals by integrating diverse evidence packets, enhancing experimental validation in model organisms.

Rapid onset fibrotic remodeling and ventricular dysfunction induced by phenylephrine involve targeted reprogramming of myocyte and fibroblast transcriptomes

This study shows that phenylephrine induces rapid fibrotic remodeling and ventricular dysfunction in mice through myocyte and fibroblast transcriptome reprogramming.

Circadian Control of Histone Turnover During Cardiac Development and Growth

This study shows Bmal1 is essential for neonatal myocyte growth, histone turnover, and chromatin organization, with Sik1 as a novel clock-controlled gene linking myocyte growth to gene transcription.